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  1. Selective serotonin reuptake inhibitors (SSRIs) - Mayo Clinic

    If one SSRI doesn't work well for you, a different one may work better. This is because SSRIs differ in how well they block serotonin reuptake and in how quickly they break down and are cleared from the …

  2. Selective Serotonin Reuptake Inhibitors - StatPearls - NCBI ...

    May 1, 2023 · As the name suggests, SSRIs exert action by inhibiting the reuptake of serotonin, thereby increasing serotonin activity. Unlike other classes of antidepressants, SSRIs have little effect on …

  3. Mechanism of Action of SSRIs (Selective Serotonin Reuptake ...

    May 31, 2025 · Learn how SSRIs work by blocking serotonin reuptake in the brain. Includes MOA, uses, side effects, MCQs, and pharmacokinetics. Learn Mechanism of Action of SSRIs

  4. How SSRIs Work: Depression & Brain Chemistry Explained

    Sep 21, 2025 · SSRIs work by increasing the concentration of serotonin in specific areas of the brain, particularly in the synaptic cleft. The synaptic cleft is the tiny gap between two neurons where …

  5. Selective Serotonin Reuptake Inhibitors: Uses & Side Effects

    Sep 26, 2025 · SSRIs (selective serotonin reuptake inhibitors) are a common type of antidepressant. They work by changing the activity of serotonin, a chemical that affects your mood, as well as many …

  6. How Antidepressants Affect the Brain - sciencenewstoday.org

    Aug 8, 2025 · These early antidepressants, known as monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), worked by increasing the levels of neurotransmitters in the brain, …

  7. How antidepressants work in the brain. - medsupport.org

    Mar 8, 2025 · SSRIs are one of the most commonly prescribed classes of antidepressants. They work by inhibiting the reabsorption (or reuptake) of serotonin into neurons. This action increases the …