Mutations in ASPM are the most frequent cause of microcephaly, a disorder characterized by reduced brain size at birth. ASPM is recognized as a major regulator of brain size, yet its role during ...

In a recent study published in Nature Communications, researchers examinea the effects of temporal morphogen gradient during neural induction (NI) on the formation of brain organoids. Study: Temporal ...

Human neural organoids, derived from pluripotent stem cells, enable the study of the highly regulated process of human brain development in vitro. In vivo, the process is shaped by strict time- and ...

Image of novel brain organoid model showing its characteristic convoluted shaped and extended neuroepithelium. The neurons present in the organoid are shown in different colors depending on their ...

In a study published in the iScience journal, a research group from Switzerland shows that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptors and entry genes are expressed in ...

Before neurogenesis, the neural tube wall consists of only one cell type, the neuroblasts, from which all neurons and glial cells derive. Neuroepithelial cells form a single-cell-layered ...