KRAS mutation type may guide more effective cancer treatments

KRAS is the most frequently mutated oncogene across all human cancers. Although different KRAS mutations have long been thought to exert the same cancer-driving effects, a new study led by UT ...
EurekAlert!

CRISPR-Cas3 gene editing system restores dystrophin function in stem cells derived from patients with Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a muscle degeneration disorder caused by mutations affecting the dystrophin gene. On August 24 th in the journal Stem Cell Reports, researchers show how a dual ...
ascopubs.org

Mutation Burden Independently Predicts Survival in the Pan-Cancer Atlas

Practices and Views of US Oncologists and Genetic Counselors Regarding Patient Recontact After Variant Reclassification: Results of a Nationwide Survey Long-standing clinical predictors of cancer ...
ascopubs.org

Ewing Sarcomas With p53 Mutation or p16/p14ARF Homozygous Deletion: A Highly Lethal Subset Associated With Poor Chemoresponse

Advanced-Stage Large-Cell Lymphoma in Children and Adolescents: Results of a Randomized Trial Incorporating Intermediate-Dose Methotrexate and High-Dose Cytarabine in the Maintenance Phase of the APO ...
The American Journal of Managed Care

Multi-Hit TP53 Mutations Have Major Impact on Posttransplant Outcomes in MF

Patients with myelofibrosis (MF) with single-hit mutations had similar outcomes to patients with wild-type TP53. People with myelofibrosis (MF) who undergo hematopoietic stem cell transplantation ...